Witherspoon migration from Pennsylvania to Indiana took place when John William Witherspoon (born: 11 Dec 1756 - died: 1 Jan 1843) moved from York County, Pennsylvania to Gibson County, Indiana along with his wife Margaret Carson, his second wife. John William travelled a lot working for the railroad, but managed to have 12 children during his life.

Among the 12 children was Jackson Deazmon Witherspoon (born: 20 April 1815 in Alabama). Jackson Deazmon died in Gibson County, IN. His first wife, Elizabeth Teel died shortly after their marriage. However, one known son was born through this union, John Logan Witherspoon.

John Logan Witherspoon (born: 16 Sep 1842 - died: 27 Jan 1886/87) died at the Andersonville Prison during the Civil War. He was a prisoner of war there and died from T.B., thought to have been caused by the lack of a decent place to live and of decent food when he was in prison. This disease caused his death at a young age and also the deaths of his wife Catherine (Scott) and his sons, Wes and Clarence, and one daughter, Edith.

However, despite the hardships of this family during the civil war, John Logan's son, William Henry Witherspoon (born: 1876 - died: 2 Sep 1927) married Emily Catherine Broadwell and together had 11 children. William Henry Witherspoon moved his family to Arkansas by covered wagon. His was killed by a fatal shotgun wound.